On May 11, 2020, the Department of Defense Office of Inspector General (DoD OIG) began the subject evaluation to provide an assessment of the efforts undertaken by U.S. Africa Command, U.S. Central Command, U.S. European Command, U.S. Indo-Pacific Command, U.S. Southern Command (USSOUTHCOM), and the Joint Staff to maintain force, mission, and readiness while responding to the Coronavirus Disease-2019 (COVID-19) pandemic and the subsequent public health crisis, This memorandum provides the results on the USSOUTHCOM response to the COVID-19 pandemic; we address the other Combatant Commands and the Joint Staff portions of this work separately.