On May 11, 2020, the Department of Defense Office of Inspector General (DoD OIG) began the subject evaluation to provide an early assessment of the efforts undertaken by U.S. Africa Command (USAFRICOM), U.S. Central Command, U.S. European Command, U.S. Indo-Pacific Command, U.S. Southern Command, and the Joint Staff to maintain force, mission, and readiness while responding to the Coronavirus Disease-2019 (COVID-19) pandemic and the subsequent public health crisis. This evaluation was conducted as a joint project bythe Evaluations and Audit Components of the DoD OIG. This report focuses on the USAFRICOM response to the COVID-19 pandemic, we will address the other Combatant Commands and the Joint Staff portions of this work separately.